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. Author manuscript; available in PMC: 2022 Dec 14.
Published in final edited form as: Circulation. 2021 Sep 30;144(24):1899–1911. doi: 10.1161/CIRCULATIONAHA.121.056456

Figure 2: Meta-Analyses of Multivariable Models Evaluating Associations Between 5 Epigenetic Age Acceleration Measures and Incident Atrial Fibrillation.

Figure 2:

(A) Horvath clock, (B) Hannum clock, (C) DNAm PhenoAge clock, (D) DNAm PAI-1 epigenetic predictor, (E) DNAm GrimAge clock.

HRs are per 5-year increment in each age measure, per standard deviation increment for DNAm PAI-1.

Analyses adjusted for technical factors (cell types, sample batch, laboratory site, and follow-up visit), chronological age, sex, race, body mass index, smoking status, smoking pack year, systolic blood pressure, diastolic blood pressure, hypertensive medication, diabetes, history of congestive heart failure, history of myocardial infarction.

CI = confidence intervals, FHS = Framingham Heart Study, ARIC = Atherosclerosis Risk in Communities, CHS = Cardiovascular Health Study.

Tests for overall effect heterogeneity performed with the Q- and I-squared statistics.