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. Author manuscript; available in PMC: 2022 Dec 14.
Published in final edited form as: Circulation. 2021 Sep 30;144(24):1899–1911. doi: 10.1161/CIRCULATIONAHA.121.056456

Table 2:

Baseline Epigenetic Age Measures of FHS, ARIC, and CHS Study Participants

FHS n = 2,362 ARIC n = 2,519 CHS n = 719
Horvath Predicted Age, years 65.0 ± 8.6 57.1 ± 9.4 70.2 ± 7.7
Horvath Predicted EAA, years 0.0 ± 5.2 0.0 ± 7.3 0.0 ± 6.4
Hannum Predicted Age, years 67.1 ± 9.3 57.1 ± 8.7 72.2 ± 7.1
Hannum Predicted EAA, years 0.0 ± 5.1 0.0 ± 6.4 0.0 ± 5.4
DNAm PhenoAge, years 58.6 ± 10.2 52.8 ± 9.1 64.2 ± 8.3
DNAm PhenoAge EAA, years 0.0 ± 6.4 0.0 ± 7.4 0.0 ± 6.8
DNAm PAI-1* 19,696.4 ± 3201.6 21,467.0 ± 2825.0 24,382.0 ± 2,994.0
DNAm PAI-1* EAA 0.0 ± 3,153.9 0.0 ± 2,800.0 0.0 ± 2,993.0
DNAm GrimAge, years 59.2 ± 8.7 57.6 ± 7.2 71.7 ± 5.7
DNAm GrimAge EAA, years 0.0 ± 4.8 0.0 ± 5.8 0.0 ± 4.4

Data are n (%) or mean ± standard deviation.

*

DNAm PAI-1 is an epigenetic predictor of plasma PAI-1 levels (picograms/milliliter). FHS = Framingham Heart Study, ARIC = Atherosclerosis Risk In Communities, CHS = Cardiovascular Health Study, EAA = epigenetic age acceleration.