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. 2021 Dec 14;12(12):1158. doi: 10.1038/s41419-021-04451-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A The overall survival curves of patients with iCCA (left), pCCA (middle), and dCCA (right) were stratified by ITGB1 expression. High ITGB1 expression indicates poor patient overall survival. B Overall survival curves of patients with iCCA (left), pCCA (middle), and dCCA (right) were further analyzed by stratifying the patients into subgroups with the double high expression, single high expression, and dual low expression of ALDH3B2 and ITGB1. A log-rank test calculated data. Double high expression of ALDH3B2 and ITGB1 was more potent in predicting patient prognosis.