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. 2021 Dec 14;12:7105. doi: 10.1038/s41467-021-27316-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Results are for the evaluable immunogenicity population. Data are presented as geometric mean values with associated 95% CIs shown as error bars. Dots represent individual 50% neutralizing titers; individual dots correspond with discrete visits for each time point and may be superimposed. Numbers within bars are the geometric means. n = Number of participants with valid and determinate assay results. GMTs, GMFRs, and two-sided 95% CIs were calculated by exponentiation of the mean logarithm of the titers or fold rises and the corresponding CIs (based on the Student t distribution). GMFRs are from before dose 1 to 1 month after dose 2. Assay results below the LLOQ (20, dashed line) were set to 0.5 × LLOQ. CI confidence interval, GMFR geometric mean fold rise, GMT geometric mean titer, NT50 50% neutralizing titer, LLOQ lower limit of quantitation, SARS-CoV-2 severe acute respiratory syndrome coronavirus 2. In the placebo group, n = 41 except before dose 2, when n = 40.