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. 2021 Dec 14;11:23996. doi: 10.1038/s41598-021-03422-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2021

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Contour plots generated in DesignExpert depicting A (amplitude, %, x-axis) versus B (duration, min., y-axis) at fixed C (temperature, °C, columns). Size (row I) and PDI (row II) responses at fixed variable C as indicated at the top of each column. Colors from warm to cool indicate values from high to low. Row III depicts overlay plots of the two responses where the criteria of size < 150 nm and PDI < 0.1 are fulfilled at each temperature.