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. 2021 Dec 14;11:24011. doi: 10.1038/s41598-021-03281-0

Table 3.

Univariate analysis of clinical and sociodemographic variables associated with CSP and final model of multivariate analysis with significant associated variables with CSP.

Variables β-coefficient 95% CI Unadjusted p-value
Age − 0.488 − 1.117 to 0.14 0.127
Gender 0.390 − 15.80 to 16.59 0.962
Time of ongoing pain (months) 0.00647 − 0.055 to 0.068 0.836
Weight (kg) 0.296 − 0.088 to 0.68 0.13
Height (m) − 28.001 − 92.556 to 36.555 0.392
BMI 1.510 0.408 to 2.618 0.008
Kellgren–Lawrence classification
Right 1.880 − 3.25 to 7.01 0.469
Left 4.690 − 0.477 to 9.859 0.075
Average total 4.089 − 1.26 to 9.44 0.133
Knee arthroplasty
Right 27.160 − 17.49 to 71.81 0.23
Left − 40.940 − 76.966 to − 4.92 0.026
Ten-minute walking test 0.580 − 0.288 to 1.45 0.188
Six-minute walking test (distance in m) − 0.036 − 0.091 to 0.019 0.199
Timed up-and-go 0.136 − 0.65 to 0.92 0.731
Berg balance scale − 0.567 − 1.29 to 0.159 0.125
Epworth sleepiness scale 1.268 0.26 to 2.27 0.014
Medical research council scale average − 6.508 − 16.507 to 3.49 0.2
WOMAC stiffness − 0.035 − 3.078 to 3.0074 0.982
WOMAC physical function 0.270 − 0.16 to 0.70 0.217
WOMAC pain 1.237 − 0.27 to 2.749 0.108
Pain pressure threshold (kPa)
Knee
 Right 0.174 − 2.194 to 2.541 0.885
 Left − 0.046 − 2.493 to 2.402 0.971
 Bilateral 0.070 − 2.378 to 2.518 0.955
Upper Limb
 Right − 0.326 − 3.277 to 2.62 0.827
 Left − 0.420 − 2.898 to 2.81 0.977
 Bilateral − 0.190 − 3.199 to 2.81 0.899
Conditioned pain modulation (kPa) 2.889 − 2.297 to 8.077 0.271
Visual analogue scale
Right 1.880 − 0.23 to 3.99 0.08
Left 0.640 − 1.52 to 2.81 0.558
Bilateral 2.369 − 0.54 to 5.28 0.11
Pain Catastrophizing Scale 0.345 − 0.21 to 0.90 0.223
HAM-D Scale 0.789 − 0.308 to 1.886 0.157
Hospital Anxiety and Depression Scale
Anxiety 0.900 − 0.53 to 2.34 0.216
Depression 0.073 − 1.65 to 1.798 0.933
Montreal cognitive assessment
Education Level (years) − 0.529 2.206 to 1.147 0.533
Total score − 1.099 − 2.328 to 0.13 0.079
Model 4. Multivariate Analysis for CSP (ms) Adjusted p-value R-Squared: 0.2120
Age − 0.929 − 1.678 to -0.181 0.016
Education 4.907 − 4.580 to 14.395 0.306
Kellgren Lawrence classification Average 6.755 0.662 to 12.848 0.030
MoCA total − 2.106 − 3.64 to -0.568 0.008
HAD-anxiety − 0.434 − 2.118 to 1.250 0.609