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. 2021 Dec 14;11:23962. doi: 10.1038/s41598-021-03372-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Spontaneous motor activity (A) and performance in the pot jumping test (B) of animals repeatedly treated with CE-123 or vehicle. (For the study design see “Methods and materials”). Data are expressed as mean ± SEM. Scaling of X-axis reflects calendar days. Dotted rectangle signs the treatment period. (A): Activity counts detecting horizontal movements. (B): Upper curves, left axis: longest distance jumped; lower columns, right axis: total number of jumps in the trial. *p < 0.05 significance of the difference from the first measurement in the same group. +p < 0.05 significance of the difference between groups on the same day (repeated measures ANOVA followed by Duncan test).