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DExD/H-box helicases regulate the NLR signaling pathway. Activated inflammasomes could cleave Pro IL-1β and Pro IL-18 into mature IL-1β and IL-18. DExD/H-box helicases could also regulate NLRP3, NLRP9b, and NLRP6 inflammasomes and the NLRP6/MAVS signaling. The green arrow indicates the interaction between DExD/H-box helicases and adaptors and promotes signaling. P, phosphate; ISRE, IFN-stimulated response element; ASC, the apoptosis-associated speck-like protein containing CARD
