Table 4.
The significant enriched GO and KEGG pathways of target genes.
| ID | Term | Count | Genes | P _value |
|---|---|---|---|---|
| GO:0006355 | Regulation of transcription, DNA-templated | 61 | RALY, ZNF781, ZNF674, PTTG2, ZNF253, ZNF14, CRX, ZNF304, ZNF181, ZNF182, ZNF878, ZNF302, PSIP1, ZNF732, SAP30L, ZNF180, CCAR2, CSDC2, ZNF546, ZNF594, ZNF282, ZNF440, ZFP30, EMX2, ZNF814, ZNF883, ZNF439, CDK11A, ZNF717, ZNF711, CDK11B, SUPT6H, ZNF844, KMT2D, ZNF559, NR3C2, VENTX, ZNF514, ZNF780B, ZNF780A, ZNF175, ZNF846, LIMD1, ZNF605, ZNF700, HIP1, ZNF563, ZNF624, LZTR1, ZNF705A, ZNF569, SPTY2D1, ZNF705D, ZNF705E, NEUROG3, ATXN3, ZNF362, ZNF763, MAFA, ZNF385A, ZBTB8A | 3.93481E-13 |
| GO:0006351 | Transcription, DNA-templated | 62 | RALY, JDP2, ZNF781, FASLG, TP63, ZNF674, ZNF253, ZNF14, ZNF304, ZNF181, ZNF182, ZNF878, ZNF302, PSIP1, ZNF732, SAP30L, ZNF180, CCAR2, ZNF546, ZNF594, ZNF282, ZNF440, ZFP30, ZHX2, ZHX3, GZF1, ZNF883, ZNF439, PIAS4, ZNF717, ZNF711, SUPT6H, ZNF844, KMT2D, ZMYND11, ZNF559, NR3C2, ZNF514, ZNF780B, ZNF780A, ZNF175, ZNF846, LIMD1, ZNF700, ZNF605, HIP1, ZNF563, ZNF624, ZNF705A, ZNF569, SPTY2D1, ZNF705D, LMCD1, ZNF705E, SIRT2, ATXN3, ZNF362, ZNF763, MAFA, PBX2, ZNF385A, ZBTB8A | 5.91126E-09 |
| GO:0003677 | DNA binding | 53 | RAD51D, ZNF781, TP63, ZNF674, CRX, ZNF14, FBXL19, ZNF181, APP, ZNF182, ZNF302, H2AFX, SAP30L, ZNF180, CSDC2, ZNF546, ZNF594, ZNF282, ZNF440, ZFP30, GMEB1, ZHX2, ZHX3, ZNF883, ZNF439, PIAS4, ZNF717, ZNF711, SUPT6H, KMT2D, ZNF844, ZNF559, ZNF514, ZNF780B, ZNF780A, ZNF175, ZNF846, ZNF700, ZNF605, ZNF563, ZNF624, ZNF705A, SETBP1, ZNF569, SPTY2D1, ZNF705D, ZNF705E, ZNF362, IRF1, ZNF763, MAFA, ZNF385A, ZBTB8A | 1.04414E-07 |
| GO:0046872 | Metal ion binding | 58 | ZNF781, TP63, ZNF674, ZNF253, ZNF14, DMPK, ZNF304, POMT2, ZNF181, ZNF182, ZNF878, ZNF302, ZNF732, SAP30L, ZNF180, ZNF546, ZNF594, ZNF282, ZNF440, ZFP30, GMEB1, ZNF814, ZHX2, ADIPOR2, ZHX3, PGM2L1, GZF1, ZNF883, PPM1G, PGM3, ZNF439, ZNF717, ZNF711, PRNP, ZNF844, MGAT5B, ZNF559, USP4, ZNF514, ZNF780B, ZNF780A, ZNF175, ZNF846, ZNF700, ZNF605, ALKBH7, ZNF563, ZNF624, ZNF705A, ZNF569, NOX1, ZNF705D, ZNF705E, RNF114, ZNF362, ZNF763, ZNF385A, ZBTB8A | 1.22463E-06 |
| GO:0003676 | Nucleic acid binding | 34 | RALY, ZNF844, ZNF559, TRA2B, ZNF781, ZNF674, ZNF780B, ZNF253, ZNF514, ZNF780A, ZNF175, ZNF846, ZNF304, ZNF181, ZNF878, ZNF302, ZNF732, ZNF180, ZNF700, ZNF546, ZNF563, ZNF594, ZNF624, ZNF282, ZNF705A, ZNF440, ZFP30, ZNF569, ZNF814, ZNF439, ZNF717, ZNF763, ZNF385A, ZBTB8A | 6.76917E-06 |
| GO:0005622 | Intracellular | 40 | ZNF844, ZNF559, FGF14, RAB40C, ZNF674, ZNF780B, ZNF514, ZNF780A, ZNF175, ZNF846, ZNF304, TRIM5, ZNF181, RNF166, ZNF302, ZNF732, RAPGEF3, ZNF180, ZNF700, ZNF546, ZNF563, ZNF624, CAPN5, PIRT, IL2RA, ZNF282, RABL6, ZNF705A, ZNF440, ZFP30, ZNF569, ZNF814, RNF114, ZNF439, CCR6, ARF3, ZNF717, ZNF763, NYAP1, TRIM77 | 9.71511E-06 |
| GO:0005634 | Nucleus | 109 | RAD51D, RALY, JDP2, PLXNA1, FGF14, PRR11, SNRPD1, ZNF781, PTTG2, ZNF253, ZNF304, ZNF181, ZNF182, ZNF302, PSIP1, H2AFX, SAP30L, ZNF180, CCAR2, ZNF594, ZNF440, EMX2, ZHX2, ZHX3, RAD1, DCAF6, ZNF439, GLUL, PIAS4, DST, SUPT6H, ZNF844, GRB2, VENTX, ZNF514, ZNF846, SPC24, CDYL2, TEF, HIP1, ZNF624, MAFB, LPP, BECN1, LMCD1, NEUROG3, PTTG1IP, MAFA, BACH2, FIGNL1, TP63, FASLG, CTCF, ZNF674, CRX, ZNF14, TRIM5, SBDS, ZNF878, ZNF732, CSDC2, ZNF546, GSC, ZNF282, RABL6, ZFP30, GMEB1, GZF1, ZNF883, PPM1G, CDK11A, ZNF717, ZNF711, MTAP, CDK11B, PRNP, CAMK1D, ZMYND11, KMT2D, ZNF559, TRA2B, USP4, NR3C2, KIAA0101, WBP11, ZNF780B, ZNF780A, TNFRSF1B, SAPCD2, LIMD1, ZNF700, ZNF605, BCL9, ZNF563, ZNF705A, SETBP1, ZNF569, ZNF705D, ZNF705E, SIRT2, PHAX, HSP90B1, RNF114, ATXN3, ZNF362, IRF1, ZNF763, PBX2, ZBTB8A | 1.31622E-05 |
| GO:0003700 | Transcription factor activity, sequence-specific DNA binding | 28 | JDP2, BACH2, NR3C2, TP63, CTCF, ZNF780B, ZNF514, ZNF780A, ZNF175, CRX, ZNF304, ZNF182, ZNF302, ZNF605, ZNF546, ZNF624, LZTR1, ZFP30, ZHX2, ZNF814, ZHX3, ZNF883, ZNF717, IRF1, ZNF711, MAFA, PBX2, SUPT6H | 8.31122E-04 |
| GO:0051726 | Regulation of cell cycle | 8 | RAD51D, FIGNL1, CDK11A, PRR11, KIAA0101, IRF1, CDK11B, SIRT2 | 2.34309E-03 |
| GO:0050684 | Regulation of mRNA processing | 3 | CDK11A, CDK11B, SUPT6H | 7.19008E-03 |
| GO:0006342 | Chromatin silencing | 4 | KMT2D, H2AFX, SIRT2, SUPT6H | 2.80589E-02 |
| GO:0070889 | Platelet alpha granule organization | 2 | VPS33B, ZNF385A | 2.90859E-02 |
| GO:0045892 | Negative regulation of transcription, DNA-templated | 14 | ZNF282, ZHX2, TP63, ZHX3, CTCF, ZNF253, LGR4, SIRT2, GAS6, GZF1, PIAS4, IRF1, LIMD1, CCAR2 | 3.26644E-02 |
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 11 | JDP2, MAFB, GMEB1, IRF1, ZNF732, CTCF, NEUROG3, MAFA, ZNF253, GZF1, CRX | 3.56281E-02 |
| hsa04060 | Cytokine-cytokine receptor interaction | 8 | IL18R1, TNFRSF1B, CCR6, IL2RA, FASLG, TNFRSF14, EDAR, CCL5 | 3.92933E-02 |
| GO:0048388 | Endosomal lumen acidification | 2 | CLCN3, FASLG | 4.33113E-02 |
| GO:0034112 | Positive regulation of homotypic cell-cell adhesion | 2 | ANK3, CCL5 | 4.33113E-02 |
| GO:0008283 | Cell proliferation | 11 | TUSC2, ZMYND11, GLUL, SBDS, SLC29A2, IL2RA, GAB1, CDK11B, PIM2, RAPGEF3, GAS6 | 4.39472E-02 |
| hsa05205 | Proteoglycans in cancer | 7 | WNT2, CTTN, GRB2, ANK3, GAB1, HBEGF, FASLG | 4.65064E-02 |