Table 1.
Summary of Reported Melanoma Cases with Neuroendocrine Differentiation.
| Case report | Melan-A | SOX10 | S100 | HMB45 | Tyrosinase | Chromogranin | SYP | CD56 | INSM1 | NF | Treatment | Outcome | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Juhlin et al., (5) | Case 1: Chest Wall | - | ND | ND | - | ND | - | + | + | + | ND | Carboplatin, Etoposide | Death |
| Case 1: Femur | + | + | ND | + | ND | - | + | + | ND | ND | Carboplatin, Etoposide | Death | |
| Eyden et al., (6) | Case 1: Cutaneous lesion | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | NR | NR |
| Case 1: Axillary Mass | + | ND | + | + | + | + | + | + | ND | + | NR | NR | |
| Case 2: Nasal Mucosal lesion | + | ND | + | + | + | + | + | + | ND | + | NR | NR | |
| Case 2: Cervical lymph node | + | ND | + | + | + | + | + | + | ND | + | NR | NR | |
| Case 3: Cutaneous lesion | + | ND | + | + | + | - | - | ND | ND | - | NR | NR | |
| Case 3: Axillary lymph node | + | ND | + | + | ND | + | + | ND | ND | + | NR | NR | |
| Case 3: Pulmonary metastasis | - | ND | + | - | - | + | - | ND | ND | - | NR | NR | |
| Katerji et al., (7) | Case 1: Esophageal mass | + | + | + | ND | ND | - | - | + | ND | ND | Pembrolizumab | Desease progression and death |
| Lee et al., (11) | Case 1: paranasal sinus | + | ND | + | + | ND | + | - | ND | ND | + | NR | Liver matastasis |
| Case 2: maxillary sinus and nasal cavity | + | ND | - | + | ND | - | - | ND | ND | + | NR | Local recurrence | |
| Case 3: nasal cavity | + | ND | + | + | ND | + | + | ND | ND | + | NR | Metastasis to lymph node | |
| Case 4: nasal cavity, ethmoid, and sphenoid sinus | + | ND | + | + | ND | + | - | ND | ND | + | NR | Local recurrence and metastasis to lymph node | |
| Case 5: nasopharyngeal space | + | ND | + | + | ND | + | - | ND | ND | + | NR | Local recurrence and tracheal metastasis |
ND, Not Done; NR, Not Reported.