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. 2021 Dec 1;11:740227. doi: 10.3389/fonc.2021.740227

Figure 4.

Figure 4

BRCA1/2 and PALB2 gene binding sites. (A) BRCA1 contains 3 mutation domains: a central N-terminal RING fingerprint domain (exons 2–7) that binds to BARD, two nuclear localization signals (NLSs) (exons 11–13) that import BRCA1 into the nucleus, and a C-terminal BRCT domain (exons 16–24) that interact with BRIP1. (B) The N-terminal region of BRCA2 interacts with PALB2. The N-terminal contains the topologically associating domain (TAD). Eight RAD51 binding sites (BRC repeats) located on the central part and TR2 located on the C-terminal bind to RAD51 to promote the RAD51-mediated DNA strand exchange process. The C-terminal contains the DNA binding domain (DBD), which includes 3 oligonucleotide/oligosaccharide-binding folds that bind to double-stranded DNA, two NLSs. (C) The N-terminal coiled-coil motif of PALB2 binds to BRCA1; the C-terminal WD-40 repeats bind to BRCA2, forming the BRCA1/PALB2/BRCA2 complex.