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. 2021 Nov 11;298(1):101406. doi: 10.1016/j.jbc.2021.101406

Figure 4.

Figure 4

c-Rel is the specific transcription factor regulating PELP1 expression.A and B, Western blot and quantitative RT–PCR analysis of PELP1. C, luciferase activity of PELP1 promoter in RAW 264.7 cells when pretreated with pentoxifylline (Ptx) for 1 h at 1 mg/ml concentration, followed by LPS (1 μg/ml) treatment for 4 h. D and E, Western blot and quantitative RT–PCR images of PELP1. F, luciferase activity of PELP1 promoter in RAW 264.7 cells when transfected with c-Rel siRNA at 50 pmol/well using Lipofectamine RNAiMax followed by LPS treatment of 1 μg/ml for 4 h. LPS, lipopolysaccharide; PELP1, proline, glutamic acid, and leucine-rich protein 1.