TABLE 3.
Values and changes in the serum biomarkers
| Variables | Abnormal MRIMean ± SD, median (IQR) or n (%) | Normal MRIMean ± SD, median (IQR) or n (%) | t/χ2/Z | p‐Value |
|---|---|---|---|---|
| Demographics | ||||
| Age of onset, years | 22.16 ± 4.27 | 23.28 ± 4.76 | −0.95 | .35 |
| Sex (male) | 21 (55.26) | 17 (68.00) | 1.02 | .31 |
| Interval between N2O abuse and hospitalization exceeding 6 months | 15.00 (39.47) | 18 (72.00) | 6.40 | .01 |
| Clinical scores | 8.29 ± 2.19 | 7.76 ± 2.35 | 0.90 | .37 |
| Laboratory biomarkers | ||||
| RBC (1012/L) | 4.23 ± 0.56 | 4.37 ± 0.62 | −0.89 | .38 |
| Hb (g/L) | 136.76 ± 17.01 | 138.80 ± 17.97 | −0.45 | .66 |
| MCV (fl) | 96.42 ± 5.29 | 94.69 ± 5.16 | 1.29 | .20 |
| Vitamin B12 (pmol/L) | 229.75 (107.53–482.00) | 216.70 (98.30–538.20) | −0.06 | .95 |
| Hcy (μmol/L) | 29.80 ± 14.57 | 32.69 ± 15.98 | −0.73 | .47 |
| Electromyography (abnormal) | 31 (81.58) | 20 (80.00) | 0.02 | .88 |
Abbreviations: Hb, hemoglobin; Hcy, homocysteine; MCV, mean corpuscular volume; MRI, magnetic resonance imaging; RBC, red blood cells.