FIGURE 4.

E2F1 regulates the miR‐107/CCND1 axis to promote malignant behaviors of glioma cells. Expression of miR‐107, E2F1 and CCND1 mRNA, and E2F1 and CCND1 protein in (a) A172 and (b) T98G cells determined by RT‐qPCR and western blot analysis, respectively; (c) Proliferation of A172 and T98G cells determined by the EdU labeling assay; (d) Migration and (e) invasion abilities of A172 and T98G cells examined by the transwell assays; (f) Apoptosis rate of A172 and T98G cells determined by flow cytometry. Data were collected from three independent experiments and presented as mean ± SD. Differences were compared by one‐way (c–f) or two‐way ANOVA (a,b), *p < .05 versus miR‐107 mimic +oe‐NC