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Scheme of the study workflow. LIHC, liver hepatocellular carcinoma; DEGs: differentially expressed genes; LASSO, the least absolute shrinkage and selection operator; ROC, receiver operating characteristic; DCA, decision curve analysis; TMB, tumor mutational burden; TICs, tumor-infiltrating immune cells; ICIs, immune checkpoint inhibitors (PD1, PD-L1, and CTLA4).
