Table 2.
Cox proportional hazards regression model of overall survival in the cancer genome atlas cohort.
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P* | HR (95% CI) | P* | |
| Age (≥65 vs. <65 years) | 1.23 (0.85, 1.78) | 0.273 | – | – |
| Sex (female vs. male) | 1.26 (0.87, 1.84) | 0.228 | – | – |
| TNM stage (II vs. I) | 1.42 (0.87, 2.32) | 0.16 | 1.07 (0.65, 1.76) | 0.792 |
| TNM stage (III vs. I) | 2.72 (1.78, 4.15) | <0.001 | 2.06 (1.33, 3.21) | 0.001 |
| TNM stage (IV vs. I) | 5.44 (1.68, 17.6) | 0.005 | 5.35 (1.65, 17.4) | 0.005 |
| Histological grade (3–4 vs. 1–2) | 1.14 (0.78, 1.67) | 0.489 | – | – |
| Ishak score (5–6 vs. 0–4) | 0.87 (0.5, 1.5) | 0.612 | – | – |
| Child–Pugh grade (B–C vs. A) | 1.66 (0.82, 3.36) | 0.159 | – | – |
| Alpha fetoprotein (>200 vs. ≤200 ng/ml) | 1.01 (0.61, 1.66) | 0.979 | – | – |
| Risk score (high vs. low) | 1.61 (1.45, 1.79) | <0.001 | 1.56 (1.4, 1.74) | <0.001 |
95% CI, 95% confidence interval; HR, hazard ratio; TNM, tumor node metastasis stage.
*Statistically significant p values are given in bold, P < 0.05.