Table 4.
Hazard ratios and 95% confidence intervals for incident tuberculosis according to diabetes mellitus state and body mass index plus stratified by smoking status and alcohol consumption.
| Diabetes mellitus | BMI (kg/m2) | Number of subjects | Number of tuberculosis | Duration (PY) | IR (/1,000 PY) | HR (95% CI)* | |
|---|---|---|---|---|---|---|---|
| Non-current (never and ex-) smoker | No | <18.5 | 285,752 | 3,328 | 2,047,072 | 1.63 | 2.28 (2.19–2.36) |
| 18.5–22.9 | 2,819,305 | 17,742 | 20,509,865 | 0.87 | 1(Ref.) | ||
| 23.0–24.9 | 1,672,452 | 6,968 | 12,218,821 | 0.57 | 0.57 (0.55–0.58) | ||
| 25.0–29.9 | 1,810,488 | 5,499 | 13,235,434 | 0.42 | 0.40 (0.38–0.41) | ||
| ≥30 | 198,220 | 454 | 1,447,483 | 0.31 | 0.33 (0.30–0.36) | ||
| Yes | <18.5 | 8,732 | 259 | 54,820 | 4.72 | 2.92 (2.58–3.31) | |
| 18.5–22.9 | 160,738 | 2,287 | 1,124,505 | 2.03 | 1.39 (1.33–1.46) | ||
| 23.0–24.9 | 168,804 | 1,436 | 1,205,836 | 1.19 | 0.83 (0.78–0.88) | ||
| 25.0–29.9 | 270,156 | 1,670 | 1,945,397 | 0.86 | 0.62 (0.58–0.65) | ||
| ≥30 | 46,499 | 171 | 336,025 | 0.51 | 0.42 (0.36–0.46) | ||
| Current smoker | No | <18.5 | 82,926 | 1,397 | 584,961 | 2.39 | 2.13 (2.01–2.26) |
| 18.5–22.9 | 925,538 | 7,160 | 6,686,723 | 1.07 | 1(Ref.) | ||
| 23.0–24.9 | 601,781 | 2,201 | 4,374,099 | 0.50 | 0.47 (0.45–0.49) | ||
| 25.0–29.9 | 719,290 | 1,505 | 5,234,240 | 0.29 | 0.28 (0.27–0.30) | ||
| ≥30 | 88,578 | 104 | 643,824 | 0.16 | 0.18 (0.15–0.23) | ||
| Yes | <18.5 | 4,628 | 189 | 28,951 | 6.53 | 3.83 (3.31–4.43) | |
| 18.5–22.9 | 64,220 | 1,245 | 442,032 | 2.82 | 1.80 (1.70–1.92) | ||
| 23.0–24.9 | 58,322 | 604 | 413,285 | 1.46 | 0.98 (0.90–1.07) | ||
| 25.0–29.9 | 87,259 | 638 | 623,998 | 1.02 | 0.75 (0.69–0.81) | ||
| ≥30 | 14,215 | 47 | 102,254 | 0.46 | 0.41 (0.31–0.55) | ||
| Non-heavy drinker | No | <18.5 | 352,631 | 4,359 | 2,520,377 | 1.73 | 2.20 (2.13–2.27) |
| 18.5–22.9 | 3,514,055 | 22,718 | 25,532,628 | 0.89 | 1(Ref.) | ||
| 23.0–24.9 | 2,089,539 | 8,360 | 15,249,521 | 0.55 | 0.55 (0.53–0.56) | ||
| 25.0–29.9 | 2,278,389 | 6,372 | 16,638,296 | 0.38 | 0.38 (0.36–0.39) | ||
| ≥30 | 256,286 | 516 | 1,869,414 | 0.28 | 0.30 (0.28–0.33) | ||
| Yes | <18.5 | 12,118 | 376 | 76,073 | 4.94 | 3.08 (2.78–3.41) | |
| 18.5–22.9 | 204,471 | 3,052 | 1,425,634 | 2.14 | 1.47 (1.42–1.53) | ||
| 23.0–24.9 | 205,311 | 1,815 | 1,463,844 | 1.24 | 0.87 (0.83–0.91) | ||
| 25.0–29.9 | 319,642 | 2,032 | 2,298,049 | 0.88 | 0.65 (0.62–0.68) | ||
| ≥30 | 54,655 | 191 | 394,631 | 0.48 | 0.41 (0.36–0.47) | ||
| Heavy drinker | No | <18.5 | 16,047 | 366 | 111,656 | 3.28 | 2.34 (2.10–2.62) |
| 18.5–22.9 | 230,788 | 2,184 | 1,663,960 | 1.31 | 1(Ref.) | ||
| 23.0–24.9 | 184,694 | 809 | 1,343,399 | 0.60 | 0.48 (0.44–0.52) | ||
| 25.0–29.9 | 251,389 | 632 | 1,831,378 | 0.35 | 0.29 (0.26–0.31) | ||
| ≥30 | 30,512 | 42 | 221,892 | 0.19 | 0.18 (0.14–0.25) | ||
| Yes | <18.5 | 1,242 | 72 | 7,698 | 9.35 | 4.38 (3.46–5.54) | |
| 18.5–22.9 | 20,487 | 480 | 140,903 | 3.41 | 1.79 (1.62–1.96) | ||
| 23.0–24.9 | 21,815 | 225 | 155,276 | 1.45 | 0.83 (0.72–0.96) | ||
| 25.0–29.9 | 37,773 | 276 | 271,346 | 1.02 | 0.64 (0.57–0.73) | ||
| ≥30 | 6,059 | 27 | 43,649 | 0.62 | 0.47 (0.32–0.68) |
*
Adjusted for age, sex, smoking status, alcohol consumption (heavy drinker or not), regular physical activity, income (lowest 20% or not), hypertension, and dyslipidemia.
BMI, body mass index; PY, person-years; IR, incidence rate; HR, hazard ratio; CI, confidence interval.