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. 2021 Dec 1;12:775659. doi: 10.3389/fimmu.2021.775659

Figure 2.

Figure 2

Targets of naturally acquired antibodies associated with complement-fixation to CSP. Plasma collected from malaria-exposed adults (n=102) were tested for (A) C1q-fixation to CSP and stratified into positive and negative groups (C1q positive, n=52; C1q negative, n=50). The C1q positive and C1q negative groups were tested for (B) IgG1 and IgG3 subclasses to CSP, and (C) IgG and (D) IgM to full-length CSP and antigens representing the N-terminal (NT), central-repeat (NANP) and C-terminal (CT) regions of CSP. Samples were tested in duplicate, and the mean of duplicates is shown along with the group median and IQR. Dotted lines represent the positivity threshold relative to malaria-naïve negative controls. Reactivity between C1q positive and C1q negative groups were compared using the Mann-Whitney U test. In panels (C, D), the odds ratio and 95% confidence interval are shown for IgG/IgM positivity to each region of CSP and C1q-fixation positivity using logistic regression; y-axis was presented on a log2 scale.