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. 2021 Nov 26;24(12):103518. doi: 10.1016/j.isci.2021.103518

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Improvement of cardiac function after MIAT knockdown in DM mice

(A) Mice with indicated treatments were processed for fast blood glucose testing once a week. Line charts of fast blood glucose levels were demonstrated.

(B) Mice with indicated treatments were processed for echocardiography examination. Representative images of mice hearts were visualized by the Vevo 1100 high resolution imaging system.

(C) Left ventricular ejection fraction (LVEF) of mice with indicated treatment was evaluated by the Vevo 1100 high resolution imaging system and plotted.

(D) Left ventricular fractional shortening (LVFS) of mice with indicated treatment was evaluated by the Vevo 1100 high resolution imaging system and plotted.

(E) Representative H&E images of mice with indicated treatment were demonstrated at ×40.

(F) Representative transmission electron microscopy images of mice with indicated treatment. Scale bar: 500 nm. n = 5 for each experiment. ∗∗∗p < 0.001 versus the control group; ^##p < 0.01 versus DM, ^###p < 0.001 versus DM.