REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Caspase-1 Rabbit pAb (A0964)	ABclonal	Cat#AB_2757485
IL1β Rabbit pAb (A16288)	ABclonal	Cat#AB_2769945
IL18 Rabbit pAb (A20473)	ABclonal	Cat#A20473
GSDMD Rabbit mAb	ABclonal	Cat#A20728
GAPDH Rabbit mAb (A19056)	ABclonal	Cat#AB_2862549
Bacterial and virus strains
lentiviral shRNA for MIAT	Gene Pharma	N/A
Biological samples
Healthy human serum sample	General Hospital of Western Theater Command	Cat#CDZYY2017KY-108
Diabetic human serum sample	General Hospital of Western Theater Command	Cat#CDZYY2017KY-108
Chemicals, peptides, and recombinant proteins
HEPES	VETEC	Cat#V900477
Glucose	VETEC	Cat#V900392
NaH2PO4·2H2O	VETEC	Cat#V900060
NaOH	VETEC	Cat#V900797
CaCl2	VETEC	Cat#V900266
CsCl	VETEC	Cat#V900481
TEACl	VETEC	Cat#V900405
L-Glutamic acid	VETEC	Cat#V900408
KH2PO4	VETEC	Cat#V900041
EGTA	VETEC	Cat#03779
Z-Asp(OtBu)-OH	VETEC	Cat#02378
CsOH	SIGMA-ALDRICH	Cat#232041
Alexa Fluor™ 488 Phalloidin	Invitrogen	Cat#A12379
NaCl	VETEC	Cat#V900058
KCl	VETEC	Cat#V900068
MgCl2·6H2O	VETEC	Cat#V900020
Pluronic F-127	Invitrogen	Cat#P3000MP
Critical commercial assays
X-treme GENE siRNA transfection reagent	Roche	4476093001
HE stain kit	Solarbio	G1120
SYBR Green I	Toyobo	QPK-201
Deposited data
Original western blot images	Mendeley	https://doi.org/10.17632/cc8bb3bthw.1
Experimental models: Cell lines
Mouse: primary cardiomyocytes cell culture	Laboratory of the General Hospital of Western Theater Command	N/A
Experimental models: Organisms/strains
Mouse: C57BL/6	Liaoning Changsheng Biotechnology Co., Ltd.	Cat#76219
Oligonucleotides
miR-214-3p
Forward Primer: No. ssD809230935, Bulge-LoopTM miR-214-3p RT Primer: No. ssD809230243	RIOBIO	N/A
Bulge-LoopTM miR-214-3p Reverse Primer: No. ssD089261711, Bulge-LoopTM miR-214-3p
Caspase-1
Forward Primer: 5’-ACACGTCTTGC CCTCATTATCT-3’	Gene Tools	N/A
Reverse Primer: 5’-ATAACCTTGGGCTT GTCTTTCA-3’
IL-1β
Forward Primer: 5’-CCCTGCAGCTGGAG AGTGTGG-3’	Gene Tools	N/A
Reverse Primer: 5’-TGTGCTCTGCTTGAGA GGTGCT-3’
MIAT
Forward Primer: 5’-TGGAACAAGTCACG CTCGATT-3’	Gene Tools	N/A
Reverse Primer: 5’- GGTATCCCAAGGAATG AAGTCTGT -3’
miR-214-3p mimic
Forward Primer: 5’-ACAGCAGGCACAGA GACCGGCAGU-3’	RIOBIO	N/A
Reverse Primer: 3’-UGUCGUCCGUGUCUG UGUCCGUCA-5’
GAPDH
Forward Primer: 5’-ATCACTGCCACCCA GAAGAC-3’	Gene Tools	N/A
Reverse Primer: 5’-TTTCTAGACGGCAG GTCAGG-3’
U6
Forward Primer: 5’-CTCGCTTCGGCAGCA CATATACT-3’	Gene Tools	N/A
Reverse Primer: 5’-ACGCTTCACGAATTTG CGTGTC-3’
Software and algorithms
ImageJ	Schneider et al., 2012	https://imagej.nih.gov/ij/