. 2021 Dec 13;11(12):e051397. doi: 10.1136/bmjopen-2021-051397

Table 2.

Baseline, clinical and follow-up information collected in the NCRCC study

	Cohort	Measurements
Baseline information	CRCSC, CRCPC	Demographic (eg, gender, education, marital status and race), family history of cancer, medical history, lifestyle factors (eg, tobacco and alcohol use history, physical activity, shift work, and sleep), diet (vegetables, red meat, white meat, fruit, soy food, milk, et al), medication use (eg, aspirin, statins, metformin, antibiotics), dietary supplement use (multivitamins, calcium), and for women, hormone replacement therapy, menopausal status, menstrual and reproductive history. Body weight, height, waist and hip circumference.
Clinical outcome	CRCSC	Diagnosis date, results of FIT and colonoscopy (number, location, size), pathological features and treatment.
Clinical outcome	CRCPC	Diagnosis date, AJCC stage, tumour location, pathological features (eg, histology, cell differentiation, lymphovascular or perineural invasion and number of positive lymph nodes), molecular features (MSI, KRAS, BRAF), imaging report (CT, colonoscopy), results of laboratory (CEA, CA199, et al), information on surgical procedures, surgical complications, treatment (ingredient, modality, timing and dose), tumour response and toxicities.
Follow-up data	CRCSC	Lifestyle factors (eg, tobacco and alcohol use history, physical activity, shift work, and sleep), diet, medication use (eg, aspirin, statins, metformin, antibiotics), dietary supplement use (multivitamins, calcium), patients’ health (diagnosis of colorectal cancer) and vital status (survivorship, date and cause of death).
	CRCPC	Lifestyle factors (tobacco and alcohol use, physical activity), patients’ health (recurrence/metastasis, treatment hospital, diagnosis of second primary cancer) and vital status (survivorship, date and cause of death)

AJCC, American Joint Committee on Cancer; CA199, carbohydrate antigen 19; CEA, carcinoembryonic antigen; CRCPC, Colorectal Cancer Patients Cohort; CRCSC, Colorectal Cancer Screening Cohort; FIT, faecal immunochemical test; MSI, microsatellite instability.