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. 2021 Dec 13;9(12):e003414. doi: 10.1136/jitc-2021-003414

Figure 2.

Figure 2

Immune subgroup classification of MSI-H CRCs. (A) Second scheme of this study: from the immune subgroup classification to next-generation sequencing analysis. (B) Comparison of the average TIL densities (average densities of CD3+ TILs and CD8+ TILs at the invasive margin and center of tumor areas) between the three immune subgroups of the 73 MSI-H CRCs and those of the 535 MSS CRCs. (C) Comparison of TLS activities (maximum diameters of peritumoral TLS) between the three immune subgroups of the 73 MSI-H CRCs and those of the 411 MSS CRCs. (****, p<0.0001; ***, p<0.001; **, 0.001≤p < 0.01; *, 0.01≤p < 0.05; ns, not significant). Immune-low, immune-low; immune-intermed, immune-intermediate; Im-high, immune-high. CRCs, colorectal cancers; MSI-H, microsatellite instability-high; MSS, microsatellite-stable; TIL, tumor-infiltrating lymphocyte; TLS, tertiary lymphoid structure.