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Schematic summary of this study. CMS, consensus molecular subtype; CRC, colorectal cancers; ICB, immune checkpoint blockade; IFN, interferon; IL, interleukin; MMR, mismatch repair; MSI-H, microsatellite instability-high; PD-1, programmed cell death protein 1; PD-L1, programmed death-ligand 1; TKI, tyrosine kinase inhibitor; 5-mC, 5-methylcytosine.
