Table 3.

Biomass analysis results—two-sample t-test on the log₁₀ change

Two sample t-test on log10 change (CHL-PLA)	N TOT	N CHL	N PLA	Mean difference (SE)*	95% CI	T value	P value
All participants with available data
Oral wash samples	40	20	20	−0.103 (0.23)	−0.59 to 0.38	−0.44	0.665
Sputum samples
No imputation	27	15	12	0.80 (0.46)	−0.15 to 1.75	1.73	0.096
Imputation†	35	19	16	0.70 (0.39)	−0.08 to 1.47	1.76	0.078
Excluding antibiotic use during study
Oral wash samples	32	17	15	−0.07 (0.29)	−0.65 to 0.51	−0.25	0.808
Sputum samples
No imputation	23	14	9	1.06 (0.53)	−0.05 to 2.17	1.99	0.060
Imputation†	28	16	12	0.98 (0.47)	0.06 to 1.89	2.09	0.036

*Chlorhexidine group change in biomass minus placebo group.

†Imputation refers to the use of multiple imputation techniques to impute the 11 missing sputum weights.

CHL, chlorhexidine; PLA, placebo; TOT, total.