TABLE 2.
OR and 95% CI for preceding comorbidity associated with the risk of CCA and CCA subtypes in Finland (all regions) 1971–2014, derived from multivariate analyses
| Risk determinant | Subtype of CCA | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Any CCA (N = 6949) | Intrahepatic (N = 2572) | Extrahepatic (N = 3555) | Unknown (N = 822) | |||||||||
| Cases (%) | OR | 95% CI | Cases (%) | OR | 95% CI | Cases (%) | OR | 95% CI | Cases (%) | OR | 95% CI | |
| Cholelithiasis | 1222 (18) | 2.3 | 2.1–2.5 | 348 (14) | 1.8 | 1.5–2.0 | 659 (19) | 2.6 | 2.4–2.9 | 215 (26) | 2.6 | 2.1–3.1 |
| Diabetes | 889 (13) | 1.0 | 0.9–1.1 | 313 (12) | 1.1 | 1.0–1.2 | 404 (11) | 0.8 | 0.7–0.9 | 172 (21) | 1.7 | 1.4–2.1 |
| Inflammatory bowel disease | 336 (5) | 2.0 | 1.6–2.4 | 69 (3) | 2.6 | 1.9–3.4 | 44 (1) | 1.4 | 1.0–2.0 | 18 (2) | 2.0 | 1.2–3.6 |
| Liver cirrhosis | 154 (2) | 2.7 | 2.3–3.1 | 145 (6) | 3.8 | 3.0–4.7 | 78 (2) | 1.6 | 1.2–2.1 | 39 (5) | 3.5 | 2.3–5.3 |
| Hepatitis C | 6 (0.1) | 1.6 | 0.6–4.2 | 4 (0.1) | 2.8 | 0.8–9.5 | 1 (0.03) | 0.7 | 0.1–5.5 | 1 (0.1) | 1.3 | 0.1–20.6 |
| Hepatitis B | 8 (0.1) | 7.0 | 2.2–21.7 | 4 (0.1) | 5.7 | 1.3–25.9 | 3 (0.1) | 16.8 | 1.6–173 | 1 (0.1) | 5.4 | 0.2–119 |
Note: The OR for liver cirrhosis is from model F2 including variables cholelithiasis, diabetes, liver cirrhosis, HBV and HCV. All other ORs are from model F1 (cholelithiasis, diabetes, inflammatory bowel disease, HBV and HCV).
Abbreviations: CCA, cholangiocarcinoma; CI, confidence interval; OR, odds ratio.