TABLE 1.
Baseline characteristics of patients and diseases
| Patients characteristics | All patients n = 98 | CD n = 58 | UC n = 40 |
|---|---|---|---|
| Male sex (n, %) | 43 (44) | 26 (45) | 17 (43) |
| Age at IBD diagnosis (median, [IQR]) | 26 [18–37] | 27 [17.25–34.75] | 25.5 [19.75–41.25] |
| Montreal classification (n, %) | L1: 10 (17) | ||
| L2: 11 (19) | E1: 3 (8) | ||
| L3: 37 (64) | E2: 13 (33) | ||
| L4: 4 (7) | E3: 24 (60) | ||
| B1: 26 (45) | S1: 2 (5) | ||
| B2: 17 (29) | S2: 9 (23) | ||
| B3: 15 (26) | S3: 26 (65) | ||
| P: 27 (47) | |||
| Tobacco use (n, %) | |||
| Active | 12 (12) | 11 (19) | 1 (3) |
| Never or former | 82 (84) | 46 (79) | 36 (90) |
| Unknown | 4 (4) | 1 (2) | 3 (7) |
| Presence of EIM (n, %) | 42 (43) | 29 (50) | 13 (33) |
| Type of EIM (n, %) | |||
| Osteoarticular | 23 (55) | 17 (59) | 6 (46) |
| Skin | 18 (43) | 12 (41) | 6 (46) |
| Liver | 5 (12) | 3 (10) | 2 (15) |
| AI pancreatitis | 1 (2) | – | 1 (8) |
| Ocular | 10 (24) | 5 (17) | 5 (39) |
| Associated IMID (n, %) | 41 (42) | 26 (45) | 15 (38) |
| Patients with >1 IMID (n, %) | 9 (9) | 6 (10) | 3 (8) |
| Type of IMID (n, %) | |||
| Ankylosing spondylarthritis | 25 (61) | 18 (69) | 7 (47) |
| Psoriasis | 12 (29) | 7 (27) | 5 (33) |
| Psoriatic arthritis | 4 (10) | 2 (8) | 2 (13) |
| Rheumatoid arthritis | 4 (10) | 2 (8) | 2 (13) |
| Others a | 7 (17) | 3 (12) | 4 (27) |
| Patient with prior surgery for IBD (n, %) | 39 (40) | 38 (66) | 1 (3) |
| Number of prior surgeries (median, IQR) | 2 [1–3] | 2 [1–3] | 1 [1–1] |
| Number of prior biologics (median, [IQR]) | 3 [3–4] | 4 [3–5] | 3 [3–4] |
| Number of prior immunomodulators (median, [IQR]) | 2 [1–2] | 2 [1–2] | 1.5 [1–2] |
| History of cancer b (n, %) | 4 (4) | 4 (7) | ‐ |
| History of serious infection c (n, %) | 13 (13) | 9 (16) | 4 (10) |
| Significant co‐morbidities (n, %) | |||
| Cardiopulmonary | 6 (6) | 5 (9) | 1 (3) |
| Others d | 11 (11) | 6 (10) | 5 (13) |
Other IMID: Generalised constitutional eczema and hyperIgE syndrome, haemolytic anaemia, asthma, morphea generalisata, iridocyclitis, lupus and Takayasu’s arteritis.
Breast cancer, hepatocarcinoma, melanoma and squamous cell cancer.
Latent tuberculosis, fistulazing pretibial abcedation (pyoderma gangrenosum), perforated diverticulitis, ophthalmic zona, cutaneous zonas, perineal abscess, sepsis (pulmonary, urinary and Clostridium), staphylococcemia, bronchopneumony, candidiasis, right ulnar osteitis and Clostridium difficile.
Diabetes, interstitial nephritis, cerebrovascular ischaemia, adrenal deficiency, venous thrombosis, liver transplantation, paroxysmal nocturnal haemoglobinuria and prothrombin mutation.