TABLE 1.
Dynamic features of HIV-1, HBV, and HCV infections in vivoa
| Location of virus and parameter | Value for virus:
|
||
|---|---|---|---|
| HIV-1 | HBV | HCV | |
| Cell-free in plasma | |||
| Half-life | 5.7 | 24 | 2.7 |
| Production clearance per day (no. of virions) | 109 | 1011 | 1012 |
| Doubling time after perturbation by plasma exchange (h) | 3.50–4.04 | ND | 4.50–4.60 |
| Mobilization of virions during plasma exchange (virions/h) | 5.15 × 104 | ND | UD |
| Daily turnover (%) | 90 | 50 | >300 |
| Productively infected cells | |||
| Half-life (days) | 2 | 10–100 | 1.7–70 |
a
The data for HIV-1 are derived from the work of Wei et al. (95), Ho et al. (39), Perelson et al. (73), and Bagnarelli et al. (2). The data for HBV are derived from the work of Nowak et al. (67). The data for HCV are derived from the work of Neumann et al. (65) and Manzin et al. (53). ND, not done; UD, undetectable.