Table 4.
Univariate and multivariate adjusted logistic regression analysis of HMGCR gene SNPs and the risk of PTVD.
| Polymorphism | Model | Crude | Multivariate* | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| rs12916 T>C | Codominant (TT/TC/CC) | 1.35 | 1.15–1.59 | <0.001 | 1.38 | 1.17–1.63 | <0.001 |
| Recessive (CC/TC+TT) | 1.37 | 1.05–1.82 | 0.024 | 1.43 | 1.08–1.90 | 0.013 | |
| Dominance (TT/TC+CC) | 1.64 | 1.27–2.12 | <0.001 | 1.68 | 1.29–2.18 | <0.001 | |
| rs2303151 C>T | Codominant (CC/CT/TT) | 1.12 | 0.90–1.39 | 0.320 | 1.12 | 0.91–1.40 | 0.297 |
| Recessive (TT/CT+TT) | 1.93 | 0.96–4.30 | 0.081 | 1.95 | 0.97–4.36 | 0.077 | |
| Dominance (CC/CT+TT) | 1.06 | 0.83–1.36 | 0.641 | 1.07 | 0.83–1.37 | 0.610 | |
| rs4629571 A>G | Codominant (AA/AG/GG) | 1.12 | 0.90–1.39 | 0.320 | 1.00 | 0.76–1.34 | 0.980 |
| Recessive (GG/AG+GG) | 1.27 | 0.43–4.60 | 0.686 | 1.17 | 0.39–4.26 | 0.79 | |
| Dominance (GG/AA+AG) | 0.99 | 0.73–1.35 | 0.945 | 0.99 | 0.73–1.36 | 0.967 | |
*
Adjusted for age and sex. HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; PTVD, premature triple-vessel disease; OR, odds ratio; CI, confidence interval.