Table 6.
Univariate and multivariate adjusted logistic regression analysis of NPC1L1 and HMGCR gene SNPs and the SYNTAX score.
| Polymorphism | Model | Crude | Multivariate* | ||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | OR | 95% CI | P | ||
| rs11763759 T>C | Codominant (TT/TC/CC) | 0.95 | 0.65–1.37 | 0.770 | 0.95 | 0.65–1.37 | 0.773 |
| Recessive (CC/TT+TC) | 0.48 | 0.08–2.88 | 0.421 | 0.51 | 0.08–3.06 | 0.460 | |
| Dominance (TT/CT+CC) | 0.98 | 0.66–1.46 | 0.914 | 0.98 | 0.66–1.45 | 0.904 | |
| rs4720470 C>T | Codominant (CC/CT/TT) | 1.07 | 0.89–1.29 | 0.464 | 1.07 | 0.89–1.28 | 0.490 |
| Recessive (TT/CT+CC) | 1.14 | 0.77–1.68 | 0.516 | 1.13 | 0.77–1.68 | 0.529 | |
| Dominance (CC/CT+TT) | 1.08 | 0.84–1.39 | 0.561 | 1.07 | 0.83–1.38 | 0.592 | |
| rs2072183 G>C | Codominant (GG/GC/ CC) | 1.08 | 0.90–1.30 | 0.415 | 1.08 | 0.90–1.30 | 0.423 |
| Recessive (CC/GG+GC) | 1.06 | 0.74–1.52 | 0.751 | 1.06 | 0.74–1.53 | 0.745 | |
| Dominance (GG/CC+GC) | 1.13 | 0.87–1.46 | 0.356 | 1.13 | 0.87–1.46 | 0.370 | |
| rs2073547 A>G | Codominant (AA/AG/GG) | 1.10 | 0.91–1.32 | 0.324 | 1.09 | 0.91–1.31 | 0.334 |
| Recessive (GG/AA+AG) | 1.08 | 0.76–1.55 | 0.673 | 1.08 | 0.76–1.55 | 0.660 | |
| Dominance (AA/AG+GG) | 1.15 | 0.89–1.49 | 0.275 | 1.15 | 0.89–1.49 | 0.294 | |
| rs12916 T>C | Codominant (TT/TC/CC) | 0.98 | 0.83–1.17 | 0.844 | 0.97 | 0.82–1.15 | 0.730 |
| Recessive (CC/TC+TT) | 0.79 | 0.60–1.05 | 0.101 | 0.78 | 0.59–1.03 | 0.074 | |
| Dominance (TT/TC+CC) | 1.25 | 0.93–1.68 | 0.142 | 1.23 | 0.92–1.66 | 0.169 | |
| rs2303151 C>T | Codominant (CC/CT/TT) | 0.98 | 0.78–1.22 | 0.827 | 0.97 | 0.78–1.21 | 0.771 |
| Recessive (TT/CT+TT) | 1.32 | 0.72–2.43 | 0.374 | 1.29 | 0.70–2.38 | 0.414 | |
| Dominance (CC/CT+TT) | 0.91 | 0.70–1.19 | 0.494 | 0.91 | 0.70–1.18 | 0.462 | |
| rs4629571 A>G | Codominant (AA/AG/GG) | 0.92 | 0.69–1.25 | 0.605 | 0.91 | 0.68–1.23 | 0.557 |
| Recessive (GG/AG+GG) | 0.74 | 0.24–2.33 | 0.609 | 0.70 | 0.22–2.20 | 0.539 | |
| Dominance (GG/AA+AG) | 0.93 | 0.67–1.30 | 0.676 | 0.93 | 0.67–1.29 | 0.644 | |
*
Adjusted for age and sex. NPC1L1, Niemann-Pick C1-like 1; HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; PTVD, premature triple-vessel disease; OR, odds ratio; CI, confidence interval; SYNTAX, Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery.