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. 2021 Dec 1;8:760394. doi: 10.3389/fmed.2021.760394

Table 3.

Interaction and association of albumin and phosphorus with all-cause mortality and cardiovascular mortality.

Model 1 Model 2 Model 3
HR (95% CI) p- value HR (95% CI) p- value HR (95% CI) p- value
All-cause mortality
Phosphorus (mmol/L) 0.81 (0.67–0.98) 0.03 1.07 (0.89–1.29) 0.48 0.71 (0.45–1.14) 0.16
Albumin (g/L) 0.92 (0.91–0.94) <0.001 0.96 (0.94–0.97) <0.001 0.93 (0.89–0.98) 0.003
Interaction <0.001 0.03 0.02
Cardiovascular mortality
Phosphorus (mmol/L) 0.83 (0.63–1.10) 0.83 1.11 (0.85–1.45) 0.45 0.75 (0.49–1.14) 0.18
Albumin (g/L) 0.94 (0.92–0.96) <0.001 0.97 (0.95–0.99) 0.01 0.95 (0.91–0.99) 0.03
Interaction 0.001 0.32 0.02

HR, hazard ratio.

*Bold indicates significance at p < 0.05.

Model 1 unadjusted.

Model 2 adjusted for: age and gender.

Model 3 adjusted: model 2+ history of diabetes and cardiovascular disease, serum levels of hemoglobin, high sensitive C-reactive protein, intact parathyroid hormone, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, low-density lipoprotein cholesterol, residual renal function, and uses of phosphate binders, calcitriol, and α-ketoacid.