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. 2021 Oct 4;2(12):100364. doi: 10.1016/j.patter.2021.100364

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Top 20 predictors selected by ML4H_EN-COX and predicted 10-year risk of CAD as a function of GPS_CAD, hip circumference, and waist circumference

(A) Predictors are ranked by leave-one-out decrease in C-statistic and colored by category (Table 2).

(B–D) Ten-year risk of CAD predicted by ML4H_EN-COX plotted at ages 45, 55, and 65 years as a function of GPS_CAD, hip circumference, and waist circumference, respectively. GPS_CAD, genome-wide polygenic score for CAD; HDL-c, HDL cholesterol; SBP, systolic blood pressure; HbA1c, hemoglobin A1C; LDL-c, LDL cholesterol; Hip circ., hip circumference; ApoB, apolipoprotein B; Waist circ., waist circumference; Father heart dz, paternal history of heart disease; Lp(A), lipoprotein a; Sibling heart dz, sibling history of heart disease; PC3, genetic principal component 3; Lipid-lowering, history of taking lipid-lowering medication.