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. 2021 Oct 4;2(12):100364. doi: 10.1016/j.patter.2021.100364

Table 3.

C-statistics for ML4HEN-COX and comparator models in holdout cohort

Model Entire holdout (n = 34,655) Men (n = 17,606) Women (n = 17,049) Age < 55 (n = 15,134) Age ≥ 55 (n = 19,521)
ML4HEN-COX 0.796
(0.784, 0.809)
ref		 0.751
(0.735, 0.767)
ref		 0.780
(0.747, 0.811)
ref		 0.825
(0.799, 0.850)
ref		 0.755
(0.737, 0.771)
ref
FRS 0.756
(0.742, 0.769)
p < 0.001		 0.690
(0.670, 0.709)
p < 0.001		 0.758
(0.728, 0.790)
p = 0.07		 0.766
(0.736, 0.794)
p < 0.001		 0.712
(0.695, 0.730)
p < 0.001
PCE 0.754
(0.739, 0.768)
p < 0.001		 0.689
(0.671, 0.707)
p < 0.001		 0.749
(0.719, 0.781)
p = 0.01		 0.770
(0.740, 0.796)
p < 0.001		 0.707
(0.688, 0.725)
p < 0.001
QRISK3 0.761
(0.747, 0.774)
p < 0.001		 0.695
(0.676, 0.714)
p < 0.001		 0.763
(0.734, 0.793)
p = 0.13		 0.790
(0.763, 0.816)
p = 0.001		 0.709
(0.691, 0.727)
p < 0.001

Bootstrapped 95% confidence intervals indicated in parentheses. p values listed below each C-statistic correspond to DeLong's test comparing each C-statistic with reference (ML4HEN-COX). C-statistics in the development cohort are displayed in Table S7.