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. 2021 Oct 4;2(12):100364. doi: 10.1016/j.patter.2021.100364

Table 4.

Categorical reclassification indices in holdout cohort when ML4HEN-COX is compared with each of the three clinical risk algorithms


Comparator model
Categorical NRI cutoff FRS PCE QRISK3
2.5% 6.0% (3.5%–8.6%) 6.6% (4.1%–9.1%) 5.8% (3.3%–8.3%)
5.0% 6.1% (3.1%–9.1%) 8.2% (5.1%–11.2%) 7.5% (4.6%–10.5%)

All reclassification indices were significant at the p < 0.001 level.