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. 2021 Dec 1;9:791643. doi: 10.3389/fcell.2021.791643

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Copyright © 2021 Du, Huang, Cao, Ran, Wu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NGR1 exerts its cardioprotective effects via upregulation of AMPK/Nrf2 signaling and HO-1 expression. (A) H9c2 cell viability was reduced by Nrf2 siRNA transfection. (B) Expression of Nrf2 and HO-1 proteins in H9c2 cells assessed by Western blot analysis (C) Densitometric analysis of Nrf2 and HO-1 expression in cardiomyocytes. (D) Nrf2 and HO-1 mRNA expression. Data are shown as mean ± SEM of three independent experiments, *p < 0.001, ^& p < 0.001, and ^# p < 0.001. LG, 5.5 mM glucose; HG, 30 mM glucose; NGR1, Notoginsenoside R1.