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. 2021 Dec 1;12:769718. doi: 10.3389/fphar.2021.769718

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Copyright © 2021 Qiu, Liu, Fang, Zhang, Wang, Peng, Chen, Liu, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Principal component analysis (PCA) and immune-infiltrating landscape of active UC. The PCA of before (A) and after (B) batch correction of all samples. (C) The distribution of 22 immune cells in all active UC patients and healthy control samples in the total set. (D) The heat map delineated the abundance of the immune cell populations in each sample of active UC and healthy controls. (E) Correlation matrix of different infiltrating immune cells. The darker the blue, the stronger the negative correlation, and the darker the red, the stronger the positive correlation. (F) Comparison of immune cell infiltration in the intestinal mucosa between active UC patients and healthy control. Blue represents the healthy control group, and red represents the active UC group.