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. 2021 Dec 1;12:769718. doi: 10.3389/fphar.2021.769718

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Copyright © 2021 Qiu, Liu, Fang, Zhang, Wang, Peng, Chen, Liu, Wang and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DEGs and modules associated with active UC. (A) Volcano map of DEGs in the intestinal mucosa between active UC patients and healthy control. Red represents up-regulated genes, green represents down-regulated genes, and black represents no significant difference genes. (B) The expression profiles of top 50 DEGs between active UC patients and healthy controls. The red to green colors represent the change from high to low expression. (C) GO enrichment analysis of DEGs. (D) KEGG pathway enrichment analysis of DEGs. (E) Module clustering dendrogram based on a dissimilarity measure (1-TOM). (F) Heatmap of the correlation between module eigengenes and active UC. DEG, differentially expressed genes. UC, ulcerative colitis. GO, the Gene Ontology. KEGG, the Kyoto Encyclopedia of Genes and Genomes analyses. TOM: topological overlap matrix.