Table 2:
Approved drugs with activity against S. aureus
| Drugs | Class/type | MICs against S. aureus (μg/ml) |
References |
|---|---|---|---|
| 5-fluoro-2'-deoxyuridine | antineoplastic | 0.0007-0.002* | [35] |
| Auranofin | anti-rheumatoid | 0.125-0.5* | [18, 19] |
| Ebselen | organoselenium compound | 0.2* | [28] |
| 5-fluorouracil | antineoplastic | 0.5 – 0.8 | [33] |
| Mitomycin-C | antineoplastic | 0.25 | [167] |
| Mithramycin | antineoplastic | 0.25 | [167] |
| Disulfiram | alcohol deterrent | 1.33 | [168] |
| Triflupromazine | antipsychotic | 2-5 | [169] |
| Dactinomycin | antineoplastic | 4 | [167] |
| Oxymetazoline | Vasoconstrictor(decongestant) | 5 | [170] |
| Daunorubicin | antineoplastic | 8 | [167] |
| Doxorubicin | antineoplastic | 16 | [167] |
| Levocabastine | antihistamines | 20 | [170] |
| Emadastine | antihistamines | 20 | [170] |
| Dicyclomine | antispasmodic | 25 | [171] |
| Prochlorperazine | antipsychotic | 20-25 | [172] |
| Simvastatin | antihyperlipidemic | 29-74 | [173] |
| Celecoxib | NSAIDs | 32 | [174] |
| Tetrahydrozoline | vasoconstrictor (decongestant) | 50 | [175] |
| Methotrexate | antineoplastic | 64 – 102 | [33] |
| Tegaserol | narcotic and analgesic | 80 | [170] |
| Amitriptyline hydrochloride | antidepressant | 100 | [176] |
| Azelastine hydrochloride | antihistaminic | 125- 250 | [177] |
| Mitpranolol | antiarrhythmic, antiglucoma | 140 | [178] |
| Promethazine | neuroleptic and antihistaminic | 125- 250 | [177] |
| Butorphanole | narcotic and analgesic | 180 | [178] |
| Diclofenac | anti-inflammatory | 200 | [179] |
| Tropicamide | anticholinergic | 200 | [178] |
| Oxyfedrine | vasodilator | 200-250 | [180] |
| Aminopterin | antineoplastic | 256 | [167] |
| Fluvastatin | antihyperlipidemic | 400 | [170] |
| Ticlopidine | anticoagulant | 450 | [170] |
| Ketamine | anesthetic | 450 | [170] |
| Proxymetacaine | anesthetic | 500 | [170] |
| Mequitazine | Antihistaminic and anticholinergic | 625-125 | [177] |
| Cyproheptadine hydrochloride | antihistaminic | 625-125 | [177] |
| Ibuprofen | NSAIDs | 1250 | [181] |
| Acetaminophen | NSAIDs | 1250 | [181] |
| Telmisartan | antihypertensive | 2000 | [170] |
| Perazine | antipsychotic | 2000 | [182] |
| Amlodipine | antihypertensive | 3000 | [175] |
| Docusate sodium | laxative | 3000 | [183] |
| Etodalac | NSAIDs | 4000 | [170] |
| Alverine | spasmolytic | 4000 | [170] |
| Fluvoxamine | thymoleptic | 4000 | [182] |
| Tolfenamic acid | NSAIDs | 5000 | [170] |
| Temozolomide | antineoplastic | 5000 | [170] |
| Acepromazine | antiemetic, sedative | 5000 | [175] |
| Riluzole | anticonvulsive, antiepileptic | 5000 | [182] |
| Tamoxifen | anti-neoplastic | 6000 | [182] |
| Solifenacin succinate | spasmolytic | 7000 | [183] |
| Perphenazine | antipsychotic | 8000 | [175] |
| Oxaprozin | NSAIDs | 13000 | [170] |
| Citalopram | antidepressant | 13000 | [183] |
| Zofenopril | ACE inhibitor | 15000 | [182] |
| Sertraline | antidepressant | 16000 | [184] |
| Chlorpromazine | antipsychotic | 20000 | [175] |
| Acebutolol | antihypertensive | 23000 | [175] |
| Clopidogrel | anticoagulant | 24000 | [183] |
*
MICs below the plasma concentration of the drug in humans