TABLE 2.
Hemostatic Alterations in Patients With Cirrhosis With Versus Without AKI at Baseline
| AKI (n = 40) | No AKI (n = 40) | P Value | |
|---|---|---|---|
| Primary hemostasis (platelets) | |||
| Platelet aggregation, Ω | |||
| Collagen 1 | 12 (7-18) | 16 (10-22) | 0.03 |
| Collagen 5 | 15 (11-20) | 22 (15-27) | 0.002 |
| ADP | 14 (9-18) | 12 (9-18) | 0.8 |
| Platelet secretion, nmol | |||
| Thrombin | 0.28 (0.20-0.40) | 0.57 (0.40-0.70) | <0.001 |
| Collagen 1 | 0.12 (0.00-0.24) | 0.34 (0.21-0.41) | <0.001 |
| Collagen 5 | 0.22 (0.14-0.33) | 0.48 (0.32-0.63) | <0.001 |
| ADP | 0.20 (0.10-0.27) | 0.38 (0.26-0.61) | <0.001 |
| VWF:Ag, % | 375 (314-587) | 347 (242-491) | 0.1 |
| VWF:RCo, % | 355 (275-464) | 357 (250-412) | 0.7 |
| VWF:CB, % | 327 (164-485) | 361 (190-429) | 0.9 |
| Secondary hemostasis (coagulation) | |||
| FVIII, % | 225 (193-266) | 181 (155-245) | 0.01 |
| FXIII, % | 41 (29-59) | 54 (41-68) | 0.01 |
| PC coagulometric, % | 25 (19-41) | 30 (22-46) | 0.05 |
| PC chromogenic, % | 27 (20-44) | 31 (23-47) | 0.1 |
| PS, % | 49 (42-57) | 55 (44-64) | 0.07 |
| AT, % | 28 (23-48) | 41 (30-51) | 0.005 |
| ETP*, nmol/L * minutes | 947.9 (792.8-1134.6) | 950.4 (850.3-1157.2) | 0.5 |
| ETP + TM*, nmol/L * minutes | 891.8 (781.5-1064.4) | 915.7 (791.7-1029.0) | 0.8 |
| ETP ratio* | 0.96 (0.93-0.98) | 0.93 (0.90-0.95) | <0.001 |
| TAT, ng/mL | 3.4 (2.2-4.5) | 2.4 (1.8-3.8) | 0.04 |
| Tertiary hemostasis (fibrinolysis) | |||
| Plasminogen, % | 25 (20-37) | 41 (27-48) | 0.001 |
| t-PA, ng/mL | 31 (22-44) | 22 (15-31) | 0.001 |
| PAI-1, ng/mL | 24 (17-39) | 28 (14-48) | 0.7 |
| α2-AP % | 57 (48-74) | 74 (58-81) | 0.002 |
| TAFIa/ai, ng/mL | 27 (20-42) | 20 (17-25) | 0.001 |
| PAP, ng/mL | 44 (39-56) | 39 (35-47) | 0.04 |
Note: Median values are reported with 25th and 75th percentile values in parenthesis.
*
Thrombin generation was undetectable in 3 patients with AKI and in 2 patients without AKI.