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. Author manuscript; available in PMC: 2021 Dec 15.
Published in final edited form as: Biochemistry. 2021 Jun 22;60(26):2116–2129. doi: 10.1021/acs.biochem.0c00958

Scheme 1. Viral Restriction Mechanism of Mammalian Viperina.

Scheme 1.

aConversion of CTP to ddhCTP by mammalian viperins. ddhCTP then acts as a small molecule chain terminator against the RNA-dependent RNA-polymerases (RdRp) from multiple flaviviruses, inhibiting the replication of the viral genomes.1