Table 5.

Multivariate results – association of covariates with NPT-14 baseline, NFL baseline, NPT change over time, and NFL change over time.

Variable	Beta estimate	P value	95% CI (lower, upper)
Outcome = NPT-14 baseline
Age	0.000525	0.9969	−0.2739, 0.2750
Female sex	−3.2748	0.2562	−9.0318, 2.4822
CSF CD4+	0.002396	0.0173*	0.000449, 0.004344
CSF CD8+	−0.00029	0.5289	−0.00121, 0.000632
CSF percentage HLA-DR+ CD8+ T cells	0.07469	0.4514	−0.1243, 0.2737
CSF percentage non-classical monocytes	5.1778	0.5724	−13.2536, 23.6092
log CSF HIV RNA	−1.5744	0.2511	−4.3115, 1.1627
Outcome = NFL baseline
Age	234.30	0.2999	−217.49, 686.09
Female sex	−4168.45	0.3783	−13,646, 5309.30
CSF CD4+	0.1884	0.9058	−3.0178, 3.3946
CSF CD8+	−0.9800	0.1977	−2.4946, 0.5345
CSF percentage HLA-DR+ CD8+ T cells	−198.33	0.2274	−525.90, 129.23
CSF percentage non-classical monocytes	−1858.89	0.9018	−32,202, 28,485
log CSF HIV RNA	5755.84	0.0137*	1249.69, 10,262
Outcome = NPT-14 change
Age	0.1762	0.1700	−0.08325, 0.4357
Female sex	−6.4043	0.0134*	−11.3011, −1.5075
CSF CD4+ baseline	−0.00085	0.1578	−0.00207, 0.000364
CSF CD8+ baseline	0.000226	0.4158	−0.00035, 0.000799
CSF % HLA-DR+ CD8+ T cells baseline	−0.2511	0.0056*	−0.4181, −0.08417
CSF % non-classical monocytes baseline	−2.7496	0.7314	−19.3755, 13.8764
log CSF HIV RNA baseline	−0.4862	0.6630	−2.7990, 1.8266
Outcome = NFL change
Age	−192.91	0.6912	−1199.98, 814.17
Female sex	6695.85	0.4674	−12,308, 25,700
CSF CD4+ baseline	0.4785	0.8329	−4.2347, 5.1917
CSF CD8+ baseline	0.9218	0.3938	−1.3009, 3.1444
CSF % HLA-DR+ CD8+ T cells baseline	339.36	0.2845	−308.54, 987.27
CSF % non-classical monocytes baseline	4890.66	0.8748	−59,632, 69,414
log CSF HIV RNA baseline	−8559.65	0.0603	−17,535, 415.86

P values < .05 are denoted by asterisk.