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. 2021;21(4):517–527.

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Copyright: © Journal of Musculoskeletal and Neuronal Interactions

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ex vivo muscle force and fatigue characteristics of EDL (A-D) and SOL (E-H) from WT and OI mice after seven-week of voluntary wheel running. Data represent mean ± SEM. n=7-10/group. Ctrl, control – blocked running wheel; WR, wheel running. Isolated muscle force-frequency relationship reported in absolute (g of force; panels A and E) and specific (N/cm²; panels B and F). Muscle force-frequency relationship expressed as percentage of each muscle’s maximal force (%T_max) (C, D, G and H). Force production during the fatigue protocol expressed as percentage of each muscle’s own maximal force (%T_max) (D and H). Symbols: open circle, WT control – blocked running wheel; black circle, WT wheel running; open square, OI control – blocked running wheel; black square, OI wheel running. Statistical significance was evaluated by two-way ANOVA for repeated measures followed by Bonferroni post-hoc test: Effect of Wheel running: not significant; Effect of Genotype: ^bp<0.05.