Table 2.
Structural and biomechanical characteristics of the right femora.
| WT | OI | |||
|---|---|---|---|---|
| Ctrl (n=10) | WR (n=10) | Ctrl (n=6) | WR (n=8) | |
| Bone length (mm) | 14.6 ± 0.1 | 14.9 ± 0.1 | 13.7 ± 0.2 bb | 14.3 ± 0.1 b |
| BV/TV (%) | 12.7 ± 0.4 | 11.5 ± 0.5 | 4.88 ± 0.8 bbb | 4.79 ± 0.3 bbb |
| Tb.N.(1/mm) | 42.7 ± 0.5 | 42.3 ± 0.6 | 33.4 ± 1.5 bbb | 33.7 ± 0.6 bbb |
| Tb.Th.(µm) | 2.9 ± 0.1 | 2.7 ± 0.1 | 1.4 ± 0.2 bbb | 1.4 ± 0.1 bbb |
| Periosteal diameter (mm) | 1.44 ± 0.01 | 1.49 ± 0.02 | 1.29 ± 0.02 bbb | 1.31 ± 0.02 bbb |
| Endosteal diameter (mm) | 1.06 ± 0.01 | 1.12 ± 0.02 | 0.98 ± 0.03 b | 1.00 ± 0.02 bbb |
| Cortical thickness (mm) | 0.19 ± 0.02 | 0.19 ± 0.01 | 0.16 ± 0.01 bbb | 0.16 ± 0.01 bbb |
| Maximum load (N) | 16.4 ± 0.3 | 15.7 ± 0.4 | 7.6 ± 0.4 bbb | 7.8 ± 0.7 bbb |
| Fracture load (N) | 12.1 ± 0.4 | 10.9 ± 0.6 | 6.9 ± 0.7 bbb | 6.7 ± 1.1 bb |
| Energy until fracture (mJ) | 6.8 ± 0.4 | 7.3 ± 0.5 | 0.5 ± 0.2 bbb | 0.4 ± 0.2 bbb |
| Stiffness (N/mm) | 119.2 ± 1.9 | 115.2 ± 3.1 | 80.4 ± 5.3 bbb | 88.6 ± 5.4 bbb |
Data represent mean ± SEM. Statistical analysis: two-way ANOVA for single measurements with Bonferroni post-hoc test: Effect of Wheel running: not significant; Effect of Genotype:
b
p<0.05,
bb
p<0.01,
bbb
p<0.001. WT: Wild type; OI: Osteogenesis Imperfecta; Ctrl: Control; WR: Wheel Running; BV/TV: Bone Volume/Total Volume; Tb.N.: Trabecular Numbers; Tb.Th.; Trabecular Thickness; N: Newtons; mm: millimeters; mJ: micro Joules.