Table 1.
Demographic information for Cohort 1.
| Main Clinical Variables | Clinical Phenotypes | ||||
|---|---|---|---|---|---|
| HC, n = 10 | D1, n = 11 | D2, n = 7 | D3, n = 5 | ESRD, n = 7 | |
| Age (years ± SD)* | 36.6 ± 10.5 | 58.8 ± 6.4 | 61.4 ± 9.3 | 63.4 ± 4.2 | 57.4 ± 11.6 |
| Sex (F/M) | 7/3 | 7/4 | 4/3 | 1/4 | 4/3 |
| Ethnicity | 0/10 | 0/11 | 1/6 | 0/5 | 1/6 |
| (Hispanic/Non-Hispanic) | |||||
| sCr (mg/dL ± SD)* | 0.9 ± 0.1 | 0.9 ± 0.2 | 1.1 ± 0.3 | 1.5 ± 0.4 | 4.7 ± 2.4 |
| eGFR (mL/min/1.73 m2 ± SD)* | 82 ± 17.0 | 76.7 ± 19.5 | 65.3 ± 21.2 | 53.7 ± 22.1 | 20.8 ± 10.4 |
| Albuminuria (mg/day ± SD)* | – | 12.4 ± 7.2 | 89.3 ± 76.4 | 738.2 ± 248.25 | – |
| Duration of Diabetes (years ± SD) | – | 12.0 ± 6.7 | 12.7 ± 8.2 | 16.6 ± 5.9 | 15.4 ± 7.9 |
| BMI (kg/m2 ± SD) | 25.8 ± 6.7 | 35.0 ± 6.5 | 39.6 ± 7.8 | 32.0 ± 2.0 | 34.7 ± 2.7 |
| SBP (mmHg ± SD) | 124.4 ± 26.9 | 119.8 ± 11.0 | 120.6 ± 10.8 | 118.0 ± 21.3 | 135.3 ± 14.9 |
| DBP (mmHg ± SD) | 74.5 ± 14.9 | 68.6 ± 6.9 | 61.4 ± 5.9 | 62.8 ± 7.8 | 68.2 ± 8.3 |
| HgA1c (nmol/mL/min ± SD) | – | 8.7 ± 1.7 | 7.7 ± 1.3 | 8.1 ± 1.0 | 7.8 ± 1.5 |
| Total Cholesterol (mg/dL ± SD) | 187 ± 15.0 | 157.8 ± 30.4 | 150.1 ± 14.4 | 160.6 ± 35.0 | 124.3 ± 19.3 |
| Insulin Therapy | 0/10 (0%) | 9/11 (82%) | 5/7 (74%) | 5/5 (100%) | 5/7 (74%) |
| ACEi/ARB Therapy | 0/10 (0%) | 11/11 (100%) | 7/7 (100%) | 5/5 (100%) | 5/7 (74%) |
*p < 0.05. SD, Standard Deviation; HC, Healthy controls; D1, diabetes with normoalbuminuria; D2, diabetes with microalbuminuria; D3, diabetes with macroalbuminuria; sCr, serum creatinine; eGFR, estimated glomerular filtration rate; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HgA1c, Hemoglobin A1c; ACEi, angiotensin converting enzyme inhibitor; ARB, angiotensin II receptor blocker.