Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 15;22:341. doi: 10.1186/s13059-021-02546-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — Simulated data compared to ss2-iPSC empirical scRNA-seq data. (a) PCA plots of cells colored by individual (max 50 cells shown per individual). (b) The distribution of cell silhouette widths using the individual as the cluster. The distributions are shown for cells grouped by type (left) and by type and individual (right), with the point and whisker showing the mean and standard deviation. (c) The percentage of genes (y-axis) with a given percentage of variance explained by individual. (d) The mean-variance relationship. The counts per gene were mean-aggregated (a.counts) across nCells from each individual and logged before calculating the population wide mean and variance. All cells were used from the empirical data (average = 52), while simulated data was down-sampled to nCells per individual