Table 7.

Diagnostic accuracy of various biomarkers in identifying Crohn’ s disease in active stage

Biomarkers	AUROC	95% CI	P value	Cut-off	Sensitivity	Specificity	PV +	PV −	LR +	LR −
RDW	0.661	0.615–0.707	< 0.001	14.0	0.65	0.62	0.66	0.61	1.71	0.57
ESR	0.849	0.816–0.882	0.188	21.0	0.70	0.87	0.86	0.72	5.45	0.35
CRP	0.916	0.893–0.938	< 0.001	14.8	0.77	0.89	0.89	0.78	7.32	0.26
NLR	0.758	0.717–0.798	< 0.001	3.32	0.66	0.75	0.75	0.67	2.65	0.45
PLR	0.739	0.698–0.781	< 0.001	247	0.57	0.79	0.75	0.62	2.75	0.55
LMR	0.754	0.714–0.795	< 0.001	2.67	0.79	0.61	0.69	0.73	2.04	0.34
Fibrinogen	0.869	0.839–0.899	Ref	3.87	0.77	0.81	0.82	0.76	4.12	0.28

DeLong test was used to compare the AUROC between fibrinogen and other biomarkers and estimate P values and fibrinogen was the reference. AUROC area under the receiver operating characteristic curve; CI confidence interval; PV + positive predictive value; PV − negative predictive value; LR + positive likelihood ratio; LR − negative likelihood ratio; RDW red cell distribution width; ESR erythrocyte sedimentation rate; CRP C-reactive protein; NLR neutrophil to lymphocyte ratio; PLR platelet to lymphocyte ratio; LMR lymphocyte to monocyte ratio