Table 1.
Clinical laboratory findings
| Variable | Reference range | Hospital day 1 (day 6 of the illness) | Hospital day 8 (day 13 of the illness) | Hospital day 16 (day 21 of the illness) | Hospital day 23 (day 28 of the illness) | Day 55 of the illness |
|---|---|---|---|---|---|---|
| White blood cells (× 109/L) | 3.5–9.5 | 9.93 | 7.08 | 4.81 | 3.24 | 5.16 |
| Total neutrophils (× 109/L) | 1.8–6.3 | 9.22 | 6.2 | 3.53 | 2.73 | 3.36 |
| Total lymphocytes (× 109/L) | 1.1–3.2 | 0.39 | 0.31 | 0.63 | 0.31 | 1.24 |
| CD4+ T (#/µL) | 550–1440 | – | 258 | 292 | 72 | - |
| Platelet count (× 109/L) | 125–350 | 172 | 115 | 174 | 112 | 99 |
| Hemoglobin (g/L) | 130–175 | 144 | 109 | 104 | 92 | 115 |
| Alanine aminotransferase (U/L) | ≤ 41 | 20 | – | 22 | – | – |
| Aspartate aminotransferase (U/L) | ≤ 40 | 33 | – | 25 | – | – |
| Blood glucose | 4.11–6.05 | 6.08 | 6.42 | 5.46 | 8.84 | – |
| Lactate dehydrogenase (U/L) | 135–225 | – | 443 | 465 | 245 | 264 |
| Blood urea nitrogen (mmol/L) | 3.6–9.5 | 38.7 | – | 17.8 | – | 15.1 |
| Blood creatinine (µmol/L) | 59–104 | 233 | – | 145 | – | 112 |
| Blood uric acid (µmol/L) | 202–416 | 644 | – | 262 | – | 422 |
| eGFR (ml/min/liter) | > 90 | 26.1 | – | 46.4 | – | 63.4 |
| High-sensitivity C-reactive protein (mg/L) | < 1.0 | – | 34.6 | – | 5.9 | – |
| Procalcitonin (ng/ml) | 0.02–0.05 | – | 0.14 | 0.09 | 0.16 | 0.07 |
| Serum ferritin (µg/L) | 30–400 | – | 1598.0 | – | 553.1 | 208.0 |
| D-dimer (µg/ml) | < 0.5 | – | 2.27 | – | 0.49 | – |
| Creatine kinase (U/L) | ≤ 7.2 | – | 12.1 | – | 3.1 | – |
| High-sensitivity cardiac troponin I (pg/ml) | ≤ 34.2 | 296.2 | 388.2 | – | 79.0 | – |
| IL-1β (pg/ml) | < 5.0 | – | < 5.0 | – | < 5.0 | < 5.0 |
| IL-2R (U/ml) | 223–710 | – | 917 | – | 791 | 466 |
| IL-6 (pg/ml) | < 7.0 | – | 31.83 | – | < 1.50 | 2.46 |
| IL-8 (pg/ml) | < 62 | – | 5.4 | – | 8.0 | 8.6 |
| IL-10 (pg/ml) | < 9.1 | – | < 5.0 | – | < 5.0 | < 5.0 |
| TNF-α (pg/ml) | < 8.1 | – | 17.4 | – | 15.2 | 15.2 |