Table 4.
Common 18 downregulated genes in flies fed on a sugar-enriched diet
| Gene | Name | Log2fold change |
Function | ||
|---|---|---|---|---|---|
| Brain | Proboscis | Leg | |||
| Lsp2 | Larval serum protein 2 | −5.40 | −8.31 | −7.30 | Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins |
| Obp99a | Odorant-binding protein 99a | −3.87 | −5.46 | −3.40 | Present in the aqueous fluid surrounding olfactory sensory dendrites and are thought to aid in the capture and transport of hydrophobic odorants into and through this fluid |
| fit | Female-specific independent of transformer | −3.14 | −3.84 | −3.08 | - |
| Lsp1beta | Larval serum protein 1 beta | −2.90 | −4.62 | −3.65 | Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins |
| Yp2 | Yolk protein 2 | −2.62 | −3.04 | −3.10 | Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis |
| Yp3 | Yolk protein 3 | −1.98 | −2.50 | −2.55 | Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis |
| Cyp4g1 | Cytochrome P450- 4g1 | −1.94 | −1.34 | −1.29 | May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides |
| Cyp12d1-p | Cyp12d1-p | −1.90 | −1.52 | −1.68 | - |
| Cp15 | Chorion protein 15 | −1.79 | −4.79 | −7.82 | Chorion membrane (egg shell) protein; plays a role in protecting the egg from the environment |
| tobi | Target of brain insulin | −1.74 | −3.46 | −2.92 | - |
| CG3699 | - | −1.57 | −1.66 | −2.93 | - |
| Nplp3 | Neuropeptide-like precursor 3 | −1.56 | −1.50 | −3.04 | - |
| CG10621 | - | −1.52 | −2.90 | −2.11 | - |
| CG3999 | - | −1.43 | −2.14 | −1.48 | - |
| dec-1 | Defective chorion 1 | −1.36 | −5.61 | −10.01 | Required for proper assembly of the eggshell |
| Vm26Aa | Vitelline membrane 26Aa | −1.36 | −4.71 | −8.72 | Major early eggshell protein |
| Vm34Ca | Vitelline membrane 34Ca | −1.35 | −4.84 | −9.19 | Major early eggshell protein |
| Yp1 | Yolk protein 1 | −1.22 | −1.78 | −1.99 | Vitellogenin is the major yolk protein of eggs where it is used as a food source during embryogenesis |
| CG4408 | - | −1.21 | −2.04 | −1.75 | - |
| CG34166 | - | −1.14 | −2.30 | −2.15 | - |
A total of 18 genes, including several that code for yolk and serum proteins, were found to decrease in the brain, proboscis, and legs of flies fed on the sugar-enriched diet. For each gene, fold change is represented as log (base2) ratios and FDR < 0.05.