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. 2021 Nov 11;12(48):16035–16053. doi: 10.1039/d1sc02963k

Scheme 1. Synthesis of pre-ligands [dtapbmiH2](PF6)2 and [daapbmiH2](PF6)2. (a) Imidazole (3 eq.), K2CO3 (5 eq.), CuI, l-proline, DMSO, 140 °C; (b) Br-pMe-Ph (3 eq.), Pd2dba3, XPhos, t-BuONa, toluene, 110 °C; (c) Br-pOMe-Ph (3 eq.), Pd2dba3, CyJohnPhos, t-BuONa, toluene, 110 °C; (d) MeOTf, C2H4Cl2, 95 °C.

Scheme 1