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. 2021 May 18;224(12):2094–2104. doi: 10.1093/infdis/jiab266

Figure 4.

Figure 4.

Metronidazole treatment is associated with changes in concentrations of immune mediators in cervicovaginal lavage (CVL) fluid. Concentration of CXCL9 in CVL at visit 1 in patients who subsequently did or did not respond to metronidazole treatment as defined by change in Shannon diversity index (A). The change (Δ) between visit 3 and visit 1 in CVL fluid concentrations of CXCL9 (B), CXCL10 (C), monocyte chemoattractant protein 1 (MCP-1; D), interleukin 1α (IL-1α; E), interleukin 1β (IL-1β; F), secretory leukocyte protease inhibitor (SLPI; G), and Escherichia coli inhibitory activity (H) comparing responders and nonresponders to metronidazole. Circles indicate Bronx and triangles Thika participants. Data are presented as mean plus standard error and asterisks indicate differences between responders and nonresponders (*P < .05, **P < .01, ***P < .001, ****P < .0001).