Table 2.
Vaginal pH, Nugent Scores, and Concentrations of Immune Mediators (Log10 pg/mL) in Cervicovaginal Lavage Fluid at Each Visit
| Mediators | Bronx | Thika | ||||||
|---|---|---|---|---|---|---|---|---|
| Visit 1 | Visit 2 | Visit 3 | P Valuea | Visit 1 | Visit 2 | Visit 3 | P Valuea | |
| Vaginal pH | 5.44 ± 0.54 | 4.68 ± 0.80 | 4.68 ± 0.46 | .0005 | 5.49 ± 0.47 | 4.94 ± 0.77 | 5.08 ± 0.54 | .01 |
| Nugent score | 7.75 ± 2.42 | 2.98 ± 3.03 | 3.51 ± 3.31 | <.0001 | 8.05 ± 1.08 | 5.86 ± 2.07 | 5.32 ± 2.17 | .01 |
| IL-1α | 2.54 ± 0.68 | 1.93 ± 0.46 | 2.00 ± 0.76 | .01 | 2.47 ± 0.71 | 2.15 ± 0.55 | 2.11 ± 0.67 | .13 |
| IL-1β | 1.46 ± 0.55 | 0.78 ± 0.84 | 0.81 ± 0.86 | .02 | 1.60 ± 0.92 | 1.25 ± 1.06 | 1.11 ± 1.13 | .20 |
| IL-6 | 0.82 ± 0.54 | 0.69 ± 0.68 | 0.77 ± 0.64 | .91 | 0.69 ± 0.82 | 0.79 ± 0.73 | 0.42 ± 0.75 | .41 |
| IL-8 | 2.82 ± 0.47 | 2.71 ± 0.42 | 2.70 ± 0.53 | .64 | 2.86 ± 0.67 | 2.83 ± 0.67 | 2.87 ± 0.68 | .91 |
| IL-10 | 0.36 ± 0.44 | 0.17 ± 0.54 | 0.20 ± 0.46 | .13 | 0.38 ± 0.58 | 0.32 ± 0.53 | 0.25 ± 0.55 | .87 |
| TNF-α | 0.03 ± 0.47 | 0.18 ± 0.52 | 0.27 ± 0.35 | .08 | 0.01 ± 0.75 | 0.07 ± 0.69 | 0.24 ± 0.37 | .97 |
| CXCL10 | 1.89 ± 0.62 | 2.14 ± 0.51 | 2.29 ± 0.67 | .04 | 1.91 ± 0.84 | 2.15 ± 0.96 | 2.37 ± 0.67 | .18 |
| MCP-1 | 1.62 ± 0.65 | 2.02 ± 0.79 | 2.10 ± 0.63 | .04 | 1.61 ± 0.95 | 1.74 ± 0.73 | 1.87 ± 0.59 | .28 |
| MIP-1β | 0.39 ± 0.33 | 0.48 ± 0.42 | 0.46 ± 0.44 | .48 | 0.54 ± 0.42 | 0.63 ± 0.50 | 0.52 ± 0.36 | .34 |
| RANTES | 0.62 ± 0.71 | 0.68 ± 1.05 | 0.59 ± 0.93 | .40 | 0.76 ± 1.11 | 0.51 ± 0.84 | 0.78 ± 0.90 | .87 |
| MIP-3α | 1.79 ± 0.53 | 1.97 ± 0.65 | 1.95 ± 0.59 | .12 | 1.39 ± 0.81 | 1.55 ± 0.86 | 1.54 ± 0.69 | .83 |
| CXCL9 | 1.83 ± 0.81 | 2.36 ± 0.66 | 2.41 ± 0.75 | .03 | 2.02 ± 0.98 | 2.35 ± 0.95 | 2.42 ± 0.84 | .50 |
| HNP1-3 | 5.30 ± 0.59 | 5.34 ± 0.65 | 5.24 ± 0.64 | .33 | 4.98 ± 0.78 | 5.03 ± 0.92 | 4.98 ± 0.72 | .90 |
| SLPI | 5.21 ± 0.63 | 5.38 ± 0.43 | 5.43 ± 0.56 | .39 | 4.943± 0.70 | 5.07 ± 0.58 | 5.10 ± 0.52 | .20 |
| IgA, ng/mL | 3.40 ± 0.30 | 3.50 ± 0.60 | 3.54 ± 0.41 | .14 | 3.24 ± 0.54 | 3.29 ± 0.53 | 3.26 ± 0.42 | .68 |
| IgG, µg/mL | 0.54 ± 0.60 | 0.53 ± 0.79 | 0.50 ± 0.70 | .53 | 0.52 ± 0.73 | 0.82 ± 0.49 | 0.76 ± 0.50 | .74 |
Data are presented as mean ± standard deviation unless otherwise indicated.
Abbreviations: HNP1–3, human neutrophil peptides 1 through 3; IgA, immunoglobulin A; IgG, immunoglobulin G; IL, interleukin; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; RANTES, regulated upon activation, normal T-cell expressed and secreted; SLPI, secretory leukocyte protease inhibitor; TNF-α, tumor necrosis factor alpha.
a P value comparing changes over the 3 visits at each site by Friedman test.